Professor and inventor Michael Demetriou has been studying immune-related diseases and cancers long before founding GlyTR Therapeutics in 2015. Prof. Demetriou’s research focuses on aberrant protein glycosylation that occurs in diseased cells. Glycosylation, the addition of sugars or glycans to proteins and other biomolecules, is an important method cells use to define the structure, function, and transportation of the molecule.
The Commercialization Award Showcase caps the end of a unique funding period. Two programs, the Commercialization Grant Award and BioENGINE & BioAccel Fellowship, granted awards to faculty and student teams, respectively, to encourage commercialization of innovations from all fields of research and stimulate entrepreneurship at UCI. The faculty and student teams presented an update on their projects and the commercialization milestones achieved over the summer at the Commercialization Award Showcase at the Cove.
A diverse mix of researchers and professors attended the Beckman Laser Institute’s Seminar at the Cove to learn about bio-photonics and its application in the fight against malaria. Prof. Bruce Tromberg introduced the day’s speakers, Prof. Jeremie Zoueu and Aboma Merdasa.
Cytochrome P450 3A4 (CYP3A4) is a key metabolizing enzyme that regulates the body’s oxidation and clearance of most drugs. Inhibition of this enzyme improves the efficacy of drug cocktails and allows for the prescription of lower, less toxic doses of pharmaceutical drugs. UCI researchers, Dr. Irina Sevrioukova, Prof. Thomas Poulos, and Prof. Richard Chamberlin have developed new CYP3A4 inhibitors that are promising candidates for pharmacotherapy use.
At the time Bruce Tromberg began his academic career at UCI as a postdoctoral scholar in 1988, the market for his research, lasers and optics in biology and medicine, was extremely small.
Despite the apparent low market value for such work, the University and BLI founders, Prof. Michael Berns and Prof. Arnold Beckman, saw the significance and worth in investing in the fields of optics and photonics. The founding researchers knew that light could be a very powerful and elegant scientific tool for studying the human body.