Of the 4.5 million snake bites that occur annually, 2.7 million are considered serious; over 100,000 people die, mostly in developing countries. Snake bites can lead to tissue necrosis, increasing damage and disability. Snakebites generally occur in rural areas that lack treatment facilities. Snakebites are currently treated by serotherapy, in which serum is administered from an immunized animal. This, however, depends on knowledge of the specific antibody required and access to a treatment facility.
The invention uses optical coherence tomography (OCT) to create a three-dimensional map of cut gemstones, both loose and in settings. This map will inform gemologists about the location and characteristics of defects, as well as more accurately measure the weight of cut gemstones that are analyzed in their settings. This information can be used to accurately determine the overall quality and monetary value of cut gemstones.
The device is an artificial corneal implant comprised of a single, nanopatterned material. The device is durable, easy to implant, and robust against bacterial infection and other problems associated with other state-of-the-art ocular devices.
Cytochrome P450 3A4 (CYP3A4) is a key metabolizing enzyme that regulates the body’s oxidation and clearance of most drugs. Inhibition of this enzyme improves the efficacy of drug cocktails and allows for the prescription of lower, less toxic doses of pharmaceutical drugs. UCI researchers, Dr. Irina Sevrioukova, Prof. Thomas Poulos, and Prof. Richard Chamberlin have developed new CYP3A4 inhibitors that are promising candidates for pharmacotherapy use.